Low-frequency parietal repetitive transcranial magnetic stimulation reduces fear and anxiety.

ABSTRACT: Anxiety disorders are the most prevalent mental disorders, with few effective neuropharmacological treatments, making treatments development critical. While noninvasive neuromodulation can successfully treat depression, few treatment targets have been identified specifically for anxiety disorders. Previously, we showed that shock threat increases excitability and connectivity of the intraparietal sulcus (IPS). Here we tested the hypothesis that inhibitory repetitive transcranial magnetic stimulation (rTMS) targeting this region would reduce induced anxiety. Subjects were exposed to neutral, predictable, and unpredictable shock threat, while receiving double-blinded, 1 Hz active or sham IPS rTMS. We used global brain connectivity and electric-field modelling to define the single-subject tar

SUBMITTER: Balderston NL 

PROVIDER: S-EPMC7026136 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature