On the relationship of first-episode psychosis to the amphetamine-sensitized state: a dopamine D_2/3 receptor agonist radioligand study.

ABSTRACT: Schizophrenia is characterized by increased behavioral and neurochemical responses to dopamine-releasing drugs. This prompted the hypothesis of psychosis as a state of "endogenous" sensitization of the dopamine system although the exact basis of dopaminergic disturbances and the possible role of prefrontal cortical regulation have remained uncertain. To show that patients with first-episode psychosis release more dopamine upon amphetamine-stimulation than healthy volunteers, and to reveal for the first time that prospective sensitization induced by repeated amphetamine exposure increases dopamine-release in stimulant-naïve healthy volunteers to levels observed in patients, we collected data on amphetamine-induced dopamine release using the dopamine D_2/3 receptor agonist radiolig

SUBMITTER: Weidenauer A 

PROVIDER: S-EPMC7026156 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature