Dataset Information

Chiari Network or Catheter-Associated Thrombus? A Rare Complication of Transseptal Access.

ABSTRACT:

SUBMITTER: Mayl J

PROVIDER: S-EPMC7026530 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Chiari Network or Catheter-Associated Thrombus? A Rare Complication of Transseptal Access.

Mayl Jonathan J Peters Luke L Zhao David D Richardson Karl K

CASE (Philadelphia, Pa.) 20191122 1

PMID: 32099939

Similar Datasets

Project description:BackgroundCatheter-associated right atrial thrombus (CRAT) is a recognised complication of central venous catheter (CVC) use for haemodialysis (HD) patients.MethodsThis was a single-centre retrospective longitudinal observational study of consecutive children aged 6 months-18 years over a 7-year period receiving in-centre chronic HD. Echocardiograms as per routine cardiac surveillance were performed 6 months or earlier given clinical concerns.ResultsSixty-five children, 36 boys (55.4%), median (IQR) age 11.8 (5.3, 14.7) years, received HD for kidney failure with replacement therapy (KFRT). Initial modality was HD in 45 (69.2%), with CVC as initial access in 42 (93.3%) and AVF in 3 (6.7%); in the remaining 20 (30.8%) patients PD was the initial modality before switching to HD. Seven of 65 (10.8%) developed CRAT at median 2 (0.8, 8.4) months from CVC insertion, with one CRAT detected 3 days following insertion. One child had 2 episodes of CRAT and one additionally thrombosed their AVF. No patient had an underlying primary kidney disease associated with a pro-thrombotic state. Those with CRAT were younger, had more frequent CVC change and received dialysis for longer duration compared to those with no CRAT. Six episodes of CRAT (75%) received anticoagulation therapy. Infective complications were observed in 25% and catheter malfunction in 50%. Five CRAT episodes (62.5%) resulted in CVC loss. One patient died after a haemorrhagic complication of anticoagulation and sepsis, and another developed life-threatening superior vena cava obstruction syndrome. Overall mortality 14% (1/7).ConclusionsThis is the first report of CRAT in a paediatric HD population. There was ~ 11% incidence of CRAT in patients receiving chronic HD detected by surveillance echocardiography. Although frequently asymptomatic, CRAT is associated with serious sequelae. Anticoagulation and surveillance with expert echocardiography remain mainstays of management. Graphical abstract.

Dataset Information

Chiari Network or Catheter-Associated Thrombus? A Rare Complication of Transseptal Access.

Publications

Chiari Network or Catheter-Associated Thrombus? A Rare Complication of Transseptal Access.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets