Step-Up Therapy in Black Children and Adults with Poorly Controlled Asthma.

ABSTRACT:

Background

Morbidity from asthma is disproportionately higher among black patients than among white patients, and black patients constitute the minority of participants in trials informing treatment. Data indicate that patients with inadequately controlled asthma benefit more from addition of a long-acting beta-agonist (LABA) than from increased glucocorticoids; however, these data may not be informative for treatment in black patients.

Methods

We conducted two prospective, randomized, double-blind trials: one involving children and the other involving adolescents and adults. In both trials, the patients had at least one grandparent who identified as black and had asthma that was inadequately controlled with low-dose inhaled glucocorticoids. We compared combinations of thera

SUBMITTER: Wechsler ME 

PROVIDER: S-EPMC7026584 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature