53BP1/RIF1 signaling promotes cell survival after multifractionated radiotherapy.

ABSTRACT: Multifractionated irradiation is the mainstay of radiation treatment in cancer therapy. Yet, little is known about the cellular DNA repair processes that take place between radiation fractions, even though understanding the molecular mechanisms promoting cancer cell recovery and survival could improve patient outcome and identify new avenues for targeted intervention. To address this knowledge gap, we systematically characterized how cells respond differentially to multifractionated and single-dose radiotherapy, using a combination of genetics-based and functional approaches. We found that both cancer cells and normal fibroblasts exhibited enhanced survival after multifractionated irradiation compared with an equivalent single dose of irradiation, and this effect was entirely dependent on

SUBMITTER: Eke I 

PROVIDER: S-EPMC7026586 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature