Myrf guides target gene selection of transcription factor Sox10 during oligodendroglial development.

ABSTRACT: Oligodendrocytes generate myelin in the vertebrate central nervous system and thus ensure rapid propagation of neuronal activity. Their development is controlled by a network of transcription factors that function as determinants of cell identity or as temporally restricted stage-specific regulators. The continuously expressed Sox10 and Myrf, a factor induced during late development, are particularly important for terminal differentiation. How these factors function together mechanistically and influence each other, is not well understood. Here we show that Myrf not only cooperates with Sox10 during the induction of genes required for differentiation and myelin formation. Myrf also inhibits the activity of Sox10 on genes that are essential during earlier phases of oligodendroglial developm

SUBMITTER: Aprato J 

PROVIDER: S-EPMC7026603 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature