Differences in the intrinsic spatial dynamics of the chromatin contribute to cell differentiation.

ABSTRACT: Advances in chromosome conformation capture techniques as well as computational characterization of genomic loci structural dynamics open new opportunities for exploring the mechanistic aspects of genome-scale differences across different cell types. We examined here the dynamic basis of variabilities between different cell types by investigating their chromatin mobility profiles inferred from Hi-C data using an elastic network model representation of the chromatin. Our comparative analysis of sixteen cell lines reveals close similarities between chromosomal dynamics across different cell lines on a global scale, but notable cell-specific variations emerge in the detailed spatial mobilities of genomic loci. Closer examination reveals that the differences in spatial dynamics mainly originat

SUBMITTER: Zhang S 

PROVIDER: S-EPMC7026660 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature