Analysis of the Clinicopathologic Characteristics of Lung Adenocarcinoma With CTNNB1 Mutation.

ABSTRACT:

Introduction

Lung adenocarcinoma with CTNNB1 mutation is relatively uncommon, and its clinicopathologic characteristics, disease course, and prognosis have not been well-studied.

Methods

A total of 564 lung adenocarcinoma patients were enrolled in this study. The relationship between CTTNB1 mutational status and clinicopathologic parameters, the rates of relapse-free survival (RFS) and overall survival (OS), and the mutational status of other genes commonly mutated in lung adenocarcinoma were analyzed.

Results

Of 564 lung adenocarcinoma patients, 30 (5.3%) harbored CTNNB1 mutations. Univariate analyses revealed that gender, smoking history, pleural invasion, and histological subtype were all significant predictors of RFS and OS. Pleural invasion a

SUBMITTER: Zhou C 

PROVIDER: S-EPMC7026668 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature