Indirect Impact of PD-1/PD-L1 Blockade on a Murine Model of NK Cell Exhaustion.

ABSTRACT: The induction of exhaustion on effector immune cells is an important limiting factor for cancer immunotherapy efficacy as these cells undergo a hierarchical loss of proliferation and cytolytic activity due to chronic stimulation. Targeting PD-1 has shown unprecedented clinical benefits for many cancers, which have been attributed to the prevention of immune suppression and exhaustion with enhanced anti-tumor responses. In this study, we sought to evaluate the role of the PD-1/PD-L1 pathway in murine natural killer (NK) cell activation, function, and exhaustion. In an in vivo IL-2-dependent exhaustion mouse model, neutralization of the PD-1/PD-L1 pathway improved NK cell activation after chronic stimulation when compared to control-treated mice. These cells displayed higher prolifera

SUBMITTER: Alvarez M 

PROVIDER: S-EPMC7026672 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature