Modifiable pathways for colorectal cancer: a mendelian randomisation analysis.

ABSTRACT:

Background

Epidemiological studies have linked lifestyle, cardiometabolic, reproductive, developmental, and inflammatory factors to the risk of colorectal cancer. However, which specific factors affect risk and the strength of these effects are unknown. We aimed to examine the relationship between potentially modifiable risk factors and colorectal cancer.

Methods

We used a random-effects model to examine the relationship between 39 potentially modifiable risk factors and colorectal cancer in 26 397 patients with colorectal cancer and 41 481 controls (ie, people without colorectal cancer). These population data came from a genome-wide association study of people of European ancestry, which was amended to exclude UK BioBank data. In the model, we used genetic variants as instr

SUBMITTER: Cornish AJ 

PROVIDER: S-EPMC7026696 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature