Identification of the cerebral effects of paracetamol in healthy subjects: an fMRI study.

ABSTRACT:

Introduction

Paracetamol is commonly used for its antipyretic properties and analgesic effects, but the central mechanism remains elusive. We designed a study in healthy volunteers to detect the central functional working mechanism of paracetamol.

Subjects material and methods

A total of 20 subjects had a baseline functional magnetic resonance imaging (fMRI) before the intake of 1000 mg paracetamol orally; 60 minutes later, a second fMRI was made aiming detection of regional blood flow differences.

Results

A decreased connectivity was observed in the ventral volume of interest (VOI), with the posterior cingulate (with both the left anterior cingulate cortex (ACC) and right ACC: respectively, Ke = 576; t = -6.8894 and Ke = 185; t = -4.8178) and the inferior temporal le

SUBMITTER: De Coster O 

PROVIDER: S-EPMC7026835 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature