Correlations between dopaminergic dysfunction and abnormal metabolic network activity in REM sleep behavior disorder.

ABSTRACT: Striatal dopamine transporter (DAT) deficiency and abnormal expression of Parkinson's disease (PD)-related pattern (PDRP) have been observed in patients with idiopathic REM sleep behavior disorder (IRBD). This study aimed to investigate the correlations between these two measures with comparison to PD using a dual tracer imaging design. Age-matched 37 IRBD patients, 86 PD patients, and 15 control subjects underwent concurrent PET scans with ¹¹C-CFT to quantify dopaminergic dysfunction and ¹⁸F-FDG to quantify PDRP expression. IRBD patients were divided into two subgroups: those with relatively normal (IRBD-RN) or abnormal (IRBD-AB) striatal DAT binding. Significantly decreased DAT binding and increased PDRP scores were present in all patient groups, except for IRBD-RN,

SUBMITTER: Huang Z 

PROVIDER: S-EPMC7026846 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature