Characterizing ipsilateral thalamic diaschisis in symptomatic cerebrovascular steno-occlusive patients.

ABSTRACT: The clinical significance of ipsilateral thalamic diaschisis (ITD) occurring after stroke is unknown. To characterize ITD, we investigate its hemodynamic, structural, and clinical implications. A single-institution prospective cross-sectional study was conducted using 28 symptomatic cerebrovascular steno-occlusive patients undergoing both BOLD-CVR and Diamox-challenged ¹⁵(O)-H₂O-PET. Follow-up was at least three months. In addition, 15 age-matched healthy subjects were included. ITD was diagnosed based on a BOLD-CVR thalamic asymmetry index (TAI) > +2 standard deviations from healthy subjects. Cerebral blood flow differences were assessed using a PET-based TAI before and after Diamox challenge. Thalamic volume masks were determined using Freesurfer. Neurological statu

SUBMITTER: Hendrik Bas van Niftrik C 

PROVIDER: S-EPMC7026850 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature