G-Protein-Coupled Receptor-Membrane Interactions Depend on the Receptor Activation State.

ABSTRACT: G-protein-coupled receptors (GPCRs) are the largest family of human membrane proteins and serve as primary targets of approximately one-third of currently marketed drugs. In particular, adenosine A₁ receptor (A₁ AR) is an important therapeutic target for treating cardiac ischemia-reperfusion injuries, neuropathic pain, and renal diseases. As a prototypical GPCR, the A₁ AR is located within a phospholipid membrane bilayer and transmits cellular signals by changing between different conformational states. It is important to elucidate the lipid-protein interactions in order to understand the functional mechanism of GPCRs. Here, all-atom simulations using a robust Gaussian accelerated molecular dynamics (GaMD) method were performed on both the inactive (antagon

SUBMITTER: Bhattarai A 

PROVIDER: S-EPMC7026935 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature