Effects of iron on the growth, biofilm formation and virulence of Klebsiella pneumoniae causing liver abscess.

ABSTRACT:

Background

Klebsiella pneumoniae is considered the most clinically relevant species of Enterobacteriaceae, known to cause severe infections including liver abscesses. To the best of our knowledge, a large proportion of iron in the human body is accumulated and stored in the liver. We hypothesize that increased iron availability is an important factor driving liver abscess formation and we therefore aim to understand the effects of iron on K. pneumoniae causing liver abscesses.

Results

All tested K. pneumoniae clinical isolates, including those isolated from liver abscesses and other abdominal invasive infection sites, grew optimally when cultured in LB broth supplemented with 50 μM iron and exhibited the strongest biofilm formation ability under those conditions. Decreased g

SUBMITTER: Chen T 

PROVIDER: S-EPMC7027070 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature