Diacron reactive oxygen metabolites and biological antioxidant potential tests for patients with age-related macular degeneration.

ABSTRACT:

Background

Previously, we showed that serum malondialdehyde (MDA) was significantly higher in patients with neovascular age-related macular degeneration (nAMD) than in those without AMD. The Diacron reactive oxygen metabolites (d-ROMs) and biological antioxidant potential (BAP) tests are known markers of oxidative stress. The aim of this study was to use d-ROMs and BAP tests to evaluate changes in systemic oxidative stress in patients with nAMD.

Methods

Blood serum samples were collected from 34 patients with nAMD (mean age: 76.5 ± 7.7 years; 22 men) and 20 control subjects (mean age: 62.9 ± 14.0 years; 10 men), and d-ROMs and BAP tests were examined.

Results

In men, the mean level of d-ROMs for the nAMD patients was significantly higher than that for the controls (31

SUBMITTER: Matsuura T 

PROVIDER: S-EPMC7027115 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature