Macrophage MSR1 promotes the formation of foamy macrophage and neuronal apoptosis after spinal cord injury.

ABSTRACT:

Background

A sustained inflammatory response following spinal cord injury (SCI) contributes to neuronal damage, inhibiting functional recovery. Macrophages, the major participants in the inflammatory response, transform into foamy macrophages after phagocytosing myelin debris, subsequently releasing inflammatory factors and amplifying the secondary injury. Here, we assessed the effect of macrophage scavenger receptor 1 (MSR1) in phagocytosis of myelin debris after SCI and explained its possible mechanism.

Methods

The SCI model was employed to determine the critical role of MSR1 in phagocytosis of myelin debris in vivo. The potential functions and mechanisms of MSR1 were explored using qPCR, western blotting, and immunofluorescence after treating macrophages and RAW264.7 with

SUBMITTER: Kong FQ 

PROVIDER: S-EPMC7027125 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature