Inducible nitric oxide synthase and systemic lupus erythematosus: a systematic review and meta-analysis.

ABSTRACT:

Background

There is a growing body of evidences indicating iNOS has involved in the pathogenesis of SLE. However, the role of iNOS in SLE is inconsistency. This systematic review was designed to evaluate the association between iNOS and SLE.

Results

Six studies were included, reporting on a total of 277 patients with SLE. The meta-analysis showed that SLE patients had higher expression of iNOS at mRNA level than control subjects (SMD = 2.671, 95%CI = 0.446-4.897, z = 2.35, p = 0.019), and a similar trend was noted at the protein level (SMD = 3.602, 95%CI = 1.144-6.059, z = 2.87, p = 0.004) and positive rate of iNOS (OR = 9.515, 95%CI = 1.915-47.281, z = 2.76, p = 0.006) were significantly higher in SLE group compared with control group. No significant difference was observed

SUBMITTER: Pan L 

PROVIDER: S-EPMC7027241 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature