Uric acid induced hepatocytes lipid accumulation through regulation of miR-149-5p/FGF21 axis.

ABSTRACT:

Background

Hyperuricemia is a major risk for non-alcoholic fatty liver disease. However, the mechanisms for this phenomenon are not fully understood. This study aimed to investigate whether microRNAs mediated the pathogenic effects of uric acid on non-alcoholic fatty liver disease.

Methods

Microarray was used to determine the hepatic miRNA expression profiles of male C57BL/6 mice fed on standard chow diet, high fat diet (HFD), and HFD combined with uric acid-lowering therapy by allopurinol. We validated the expression of the most significant differentially expressed microRNAs and explored its role and downstream target in uric acid-induced hepatocytes lipid accumulation.

Results

Microarray analysis and subsequent validation showed that miR-149-5p was significantly up-

SUBMITTER: Chen S 

PROVIDER: S-EPMC7027271 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature