Comprehensive Analysis of Differential Gene Expression to Identify Common Gene Signatures in Multiple Cancers.

ABSTRACT: BACKGROUND With the development of research on cancer genomics and microenvironment, a new era of oncology focusing on the complicated gene regulation of pan-cancer research and cancer immunotherapy is emerging. This study aimed to identify the common gene expression characteristics of multiple cancers - lung cancer, liver cancer, kidney cancer, cervical cancer, and breast cancer - and the potential therapeutic targets in public databases. MATERIAL AND METHODS Gene expression analysis of GSE42568, GSE19188, GSE121248, GSE63514, and GSE66272 in the GEO database of multitype cancers revealed differentially expressed genes (DEGs). Then, GO analysis, KEGG function, and path enrichment analyses were performed. Hub-genes were identified by using the degree of association of protein interaction n

SUBMITTER: Xue JM 

PROVIDER: S-EPMC7027371 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature