Fabrication of a Biocompatible Mica/Gold Surface for Tip-Enhanced Raman Spectroscopy.

ABSTRACT: Tip-enhanced Raman spectroscopy (TERS) is a promising technique for structural studies of biological systems and biomolecules, owing to its ability to provide a chemical fingerprint with sub-diffraction-limit spatial resolution. This application of TERS has thus far been limited, due to difficulties in generating high field enhancements while maintaining biocompatibility. The high sensitivity achievable through TERS arises from the excitation of a localized surface plasmon resonance in a noble metal atomic force microscope (AFM) tip, which in combination with a metallic surface can produce huge enhancements in the local optical field. However, metals have poor biocompatibility, potentially introducing difficulties in characterizing native structure and conformation in biomolecules, whereas

SUBMITTER: You X 

PROVIDER: S-EPMC7027439 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature