Effect of Food on the Pharmacokinetics of Quizartinib.

ABSTRACT: Quizartinib is an oral, highly potent, and selective type II FMS-like tyrosine kinase 3 inhibitor in development for acute myeloid leukemia. This parallel-group study evaluated potential food effects on quizartinib absorption in healthy subjects who received a single 30-mg dose after overnight fasting (n = 34) or a high-fat, high-calorie meal (n = 30). Blood samples were collected through 504 hours after dosing, and pharmacokinetic parameters calculated were maximum observed concentration (C_max ) and area under plasma concentration-time curve from time 0 to last quantifiable concentration (AUC_last ) and from time 0 to infinity (AUC_inf ). Mean quizartinib pharmacokinetic profiles were similar under fasted and fed conditions. The geometric least squares means

SUBMITTER: Li J 

PROVIDER: S-EPMC7027461 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature