Impact of extracardiac pathology on head growth in fetuses with congenital heart defect.

ABSTRACT:

Objective

Neurodevelopmental delay is frequently encountered in children with a congenital heart defect (CHD). Fetuses with major CHD have a smaller head circumference (HC), irrespective of altered cerebral flow or brain oxygenation. This cohort study compared head growth in cases with isolated vs those with non-isolated CHD to evaluate the effect of additional pathology on head size in these fetuses.

Method

All CHD cases diagnosed prenatally in the period January 2002-July 2014 were selected from our regional registry, PRECOR. Cases of multiple pregnancy, and those affected by maternal diabetes, severe fetal structural brain anomalies or functional CHD were excluded. Subjects were divided into groups according to whether the CHD was isolated, and the non-isolated group was

SUBMITTER: van Nisselrooij AEL 

PROVIDER: S-EPMC7027464 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature