Macronutrients modulate survival to infection and immunity in Drosophila.

ABSTRACT: Immunity and nutrition are two essential modulators of individual fitness. However, while the implications of immune function and nutrition on an individual's lifespan and reproduction are well established, the interplay between feeding behaviour, infection and immune function remains poorly understood. Asking how ecological and physiological factors affect immune responses and resistance to infections is a central theme of eco-immunology. In this study, we used the fruit fly, Drosophila melanogaster, to investigate how infection through septic injury modulates nutritional intake and how macronutrient balance affects survival to infection by the pathogenic Gram-positive bacterium Micrococcus luteus. Our results show that infected flies maintain carbohydrate intake, but reduce protein intak

SUBMITTER: Ponton F 

PROVIDER: S-EPMC7027473 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature