Normal range of complement components during pregnancy: A prospective study.

ABSTRACT:

Problem

The complement system plays a key role in normal placentation, and delicate regulation of complement system activation is critical for successful pregnancy. Therefore, establishing a normal range of complement components during pregnancy is important for clinical evaluation and research.

Methods

We performed a prospective study to investigate the normal range of complement components in circulation during different stages of pregnancy. Plasma concentrations of complement factor B (CFB), C1q, complement factor H (CFH), C3, C3c, and C4 were measured using an immunoturbidimetric assay; mannan-binding lectin (MBL), C3a, C5a, and soluble C5b-9 (sC5b-9) levels at different time points of pregnancy were determined by enzyme-linked immunosorbent assay (ELISA).

Results

SUBMITTER: He YD 

PROVIDER: S-EPMC7027513 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature