DTACC restricts bouton addition and regulates microtubule organization at the Drosophila neuromuscular junction.

ABSTRACT: Regulation of the synaptic cytoskeleton is essential to proper neuronal development and wiring. Perturbations in neuronal microtubules (MTs) are associated with numerous pathologies, yet it remains unclear how changes in MTs may be coupled to synapse morphogenesis. Studies have identified many MT regulators that promote synapse growth. However, less is known about the factors that restrict growth, despite the potential links of synaptic overgrowth to severe neurological conditions. Here, we report that dTACC, which is implicated in MT assembly and stability, prevents synapse overgrowth at the Drosophila neuromuscular junction by restricting addition of new boutons throughout larval development. dTACC localizes to the axonal MT lattice and is required to maintain tubulin levels and the inte

SUBMITTER: Chou VT 

PROVIDER: S-EPMC7027520 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature