The predicted impact and cost-effectiveness of systematic testing of people with incident colorectal cancer for Lynch syndrome.

ABSTRACT:

Objectives

To evaluate the health impact and cost-effectiveness of systematic testing for Lynch syndrome (LS) in people with incident colorectal cancer (CRC) in Australia.

Design, setting, participants

We investigated the impact of LS testing strategies in a micro-simulation model (Policy1-Lynch), explicitly modelling the cost of testing all patients diagnosed with incident CRC during 2017, with detailed modelling of outcomes for patients identified as LS carriers (probands) and their at-risk relatives throughout their lifetimes. For people with confirmed LS, we modelled ongoing colonoscopic surveillance.

Main outcome measures

Cost-effectiveness of six universal tumour testing strategies (testing for DNA mismatch repair deficiencies) and of universal germline gene pan

SUBMITTER: Kang YJ 

PROVIDER: S-EPMC7027559 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature