The Role of Excitability and Network Structure in the Emergence of Focal and Generalized Seizures.

ABSTRACT: Epileptic seizures are generally classified as either focal or generalized. It had been traditionally assumed that focal seizures imply localized brain abnormalities, whereas generalized seizures involve widespread brain pathologies. However, recent evidence suggests that large-scale brain networks are involved in the generation of focal seizures, and generalized seizures can originate in localized brain regions. Herein we study how network structure and tissue heterogeneities underpin the emergence of focal and widespread seizure dynamics. Mathematical modeling of seizure emergence in brain networks enables the clarification of the characteristics responsible for focal and generalized seizures. We consider neural mass network dynamics of seizure generation in exemplar synthetic networks a

SUBMITTER: Lopes MA 

PROVIDER: S-EPMC7027568 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature