Measurement of the penetration of 56 cosmetic relevant chemicals into and through human skin using a standardized protocol.

ABSTRACT: OECD test guideline 428 compliant protocol using human skin was used to test the penetration of 56 cosmetic-relevant chemicals. The penetration of finite doses (10 μL/cm² ) of chemicals was measured over 24 hours. The dermal delivery (DD) (amount in the epidermis, dermis and receptor fluid [RF]) ranged between 0.03 ± 0.02 and 72.61 ± 8.89 μg/cm² . The DD of seven chemicals was comparable with in vivo values. The DD was mainly accounted for by the amount in the RF, although there were some exceptions, particularly of low DD chemicals. While there was some variability due to cell outliers and donor variation, the overall reproducibility was very good. As six chemicals had to be applied in 100% ethanol due to low aqueous solubility, we compared the penetration of four ch

SUBMITTER: Hewitt NJ 

PROVIDER: S-EPMC7027575 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature