Inherited cardiac diseases, pluripotent stem cells, and genome editing combined-the past, present, and future.

ABSTRACT: Research on mechanisms underlying monogenic cardiac diseases such as primary arrhythmias and cardiomyopathies has until recently been hampered by inherent limitations of heterologous cell systems, where mutant genes are expressed in noncardiac cells, and physiological differences between humans and experimental animals. Human-induced pluripotent stem cells (hiPSCs) have proven to be a game changer by providing new opportunities for studying the disease in the specific cell type affected, namely the cardiomyocyte. hiPSCs are particularly valuable because not only can they be differentiated into unlimited numbers of these cells, but they also genetically match the individual from whom they were derived. The decade following their discovery showed the potential of hiPSCs for advancing our und

SUBMITTER: van den Brink L 

PROVIDER: S-EPMC7027796 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature