Mesenteric granulomas independently predict long-term risk of surgical recurrence in Crohn's disease.

ABSTRACT:

Aim

The risk factors that predict surgical recurrence in Crohn's disease (CD) remain controversial. Postoperative anti-tumour necrosis factor (anti-TNF) therapy might lower recurrence rates whilst the presence of mesenteric granulomas has been postulated to increase the risk. We hypothesized that mesenteric granulomas indicate disease severity and might predict the risk of surgical recurrence, irrespective of immunosuppressive therapy.

Method

We performed a retrospective review of all consecutive patients undergoing operations for CD between January 2000 and December 2014 at a single tertiary referral centre and assessed the perioperative factors and histological findings at the time of surgery. Surgical recurrence rates and the immunosuppressive regimen were assessed throug

SUBMITTER: Unger LW 

PROVIDER: S-EPMC7028106 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature