Dynamics of HIV DNA reservoir seeding in a cohort of superinfected Kenyan women.

ABSTRACT: A reservoir of HIV-infected cells that persists despite suppressive antiretroviral therapy (ART) is the source of viral rebound upon ART cessation and the major barrier to a cure. Understanding reservoir seeding dynamics will help identify the best timing for HIV cure strategies. Here we characterize reservoir seeding using longitudinal samples from before and after ART initiation in individuals who sequentially became infected with genetically distinct HIV variants (superinfected). We previously identified cases of superinfection in a cohort of Kenyan women, and the dates of both initial infection and superinfection were determined. Six women, superinfected 0.2-5.2 years after initial infection, were subsequently treated with ART 5.4-18.0 years after initial infection. We performed next-g

SUBMITTER: Pankau MD 

PROVIDER: S-EPMC7028291 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature