Interactions between core histone marks and DNA methyltransferases predict DNA methylation patterns observed in human cells and tissues.

ABSTRACT: DNA methylation and histone modifications are two major epigenetic marks in mammalian cells. Previous studies have revealed that these two mechanisms interact although a quantitative model of these is still lacking in mammalian cells. Here we sought to develop such a model by systematically evaluating the quantitative relationship between DNA methylation and the core histone modification marks in human epigenomes. This model reflects the interactions of ADD and PWWP domains of DNA methyltransferase (DNMTs) with histone 3 lysine tails. Our analysis integrated 35 whole genome bisulphite sequencing data sets (about 800 million CpG sites), 35 chromatin states and 175 ChIP-Seq histone modification profiles across 35 human cell types. The logistic regression model we built shows that more than h

SUBMITTER: Fu K 

PROVIDER: S-EPMC7028327 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature