Self-Amplified Photodynamic Therapy through the ¹ O₂ -Mediated Internalization of Photosensitizers from a Ppa-Bearing Block Copolymer.

ABSTRACT: Nanocarriers are employed to deliver photosensitizers for photodynamic therapy (PDT) through the enhanced penetration and retention effect, but disadvantages including the premature leakage and non-selective release of photosensitizers still exist. Herein, we report a ¹ O₂ -responsive block copolymer (POEGMA-b-P(MAA-co-VSPpaMA) to enhance PDT via the controllable release of photosensitizers. Once nanoparticles formed by the block copolymer have accumulated in a tumor and have been taken up by cancer cells, pyropheophorbide a (Ppa) could be controllably released by singlet oxygen (¹ O₂ ) generated by light irradiation, enhancing the photosensitization. This was demonstrated by confocal laser scanning microscopy and in vivo fluorescence imaging. Th

SUBMITTER: Liu Z 

PROVIDER: S-EPMC7028480 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature