Structured gene-environment interaction analysis.

ABSTRACT: For the etiology, progression, and treatment of complex diseases, gene-environment (G-E) interactions have important implications beyond the main G and E effects. G-E interaction analysis can be more challenging with higher dimensionality and need for accommodating the "main effects, interactions" hierarchy. In recent literature, an array of novel methods, many of which are based on the penalization technique, have been developed. In most of these studies, however, the structures of G measurements, for example, the adjacency structure of single nucleotide polymorphisms (SNPs; attributable to their physical adjacency on the chromosomes) and the network structure of gene expressions (attributable to their coordinated biological functions and correlated measurements) have not been well accomm

SUBMITTER: Wu M 

PROVIDER: S-EPMC7028505 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature