Determination of HIV status and identification of incident HIV infections in a large, community-randomized trial: HPTN 071 (PopART).

ABSTRACT:

Introduction

The HPTN 071 (PopART) trial evaluated the impact of an HIV combination prevention package that included "universal testing and treatment" on HIV incidence in 21 communities in Zambia and South Africa during 2013-2018. The primary study endpoint was based on the results of laboratory-based HIV testing for> 48,000 participants who were followed for up to three years. This report evaluated the performance of HIV assays and algorithms used to determine HIV status and identify incident HIV infections in HPTN 071, and assessed the impact of errors on HIV incidence estimates.

Methods

HIV status was determined using a streamlined, algorithmic approach. A single HIV screening test was performed at centralized laboratories in Zambia and South Africa (all participants, all

SUBMITTER: Eshleman SH 

PROVIDER: S-EPMC7028526 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature