Interleukin-27 Enforces Regulatory T Cell Functions to Prevent Graft-versus-Host Disease.

ABSTRACT: Graft-versus-host disease (GvHD) remains a significant complication of allogeneic hematopoietic cell transplantation (HCT), associated with significant morbidity and mortality. GvHD is characterized by dysregulated immune responses and resulting tissue damage of target organs. Recent investigations have focused on Foxp3⁺ regulatory T cells (Tregs) as a therapeutic tool, based on its regulatory functions in GvHD pathogenesis and their instrumental role in mitigating GvHD severity while preserving graft-versus-leukemia (GvL) activity. There are several challenges to its clinical application, including their paucity, impaired suppressive activity, and instability in vivo. Herein, we report that IL-27 pre-stimulation enhances suppressive functions of both mouse and human Treg

SUBMITTER: Le HT 

PROVIDER: S-EPMC7028690 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature