Tracing multi-isotopically labelled CdSe/ZnS quantum dots in biological media.

ABSTRACT: The strengths and limits of isotopically labelled Engineered Nanoparticles (spiked ENPs) spread in biological media have been assessed. Multi-spiked CdSe/ZnS quantum dots (QDs), measuring 7 nm and coated with thioglycolic acid (TGA), were synthesized and enriched in ⁶⁸Zn, ⁷⁷Se and ¹¹¹Cd. These QDs were dispersed at very low concentrations (0.1 to 5000 ppt) in diverse biological matrices (synthetic saliva, synthetic urine, plasma and Dulbecco's phosphate buffered saline - DPBS growth medium) and the isotopic compositions were determined by HR-ICP-MS. The initial QDs concentrations were calculated to assess the limit of quantification (QD-LOQ) according to the matrix and the isotopically enriched element. The obtained results demonstrated the advantages of th

SUBMITTER: Supiandi NI 

PROVIDER: S-EPMC7028726 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature