Surface Dependent Dual Recognition of a G-quadruplex DNA With Neomycin-Intercalator Conjugates.

ABSTRACT: G-quadruplexes have been characterized as structures of vital importance in the cellular functioning of several life forms. They have subsequently been established to serve as a therapeutic target of several diseases including cancer, HIV, tuberculosis and malaria. In this paper, we report the binding of aminosugar-intercalator conjugates with a well-studied anti-parallel G-quadruplex derived from Oxytricha Nova G-quadruplex DNA. Of the four neomycin-intercalator conjugates studied with varying surface areas, BQQ-neomycin conjugate displayed the best binding to this DNA G-quadruplex structure with an association constant of K _a = (1.01 ±0.03) × 10⁷ M^-1 which is nearly 100-fold higher than the binding of neomycin to this quadruplex. The binding

SUBMITTER: Ranjan N 

PROVIDER: S-EPMC7028757 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature