Connectivity Patterns of Subthalamic Stimulation Influence Pain Outcomes in Parkinson's Disease.

ABSTRACT: Background: Pain is highly prevalent in Parkinson's disease and is associated with significant reduction in health-related quality of life. Subthalamic deep brain stimulation can produce significant pain relief in a subset of patients after surgery. However, the mechanism by which deep brain stimulation modulates sensory function in Parkinson's disease remains uncertain. Objective: To describe the motor and pain outcomes of deep brain stimulation applied to a series of patients with Parkinson's disease and to determine whether the structural connectivity between the volume of tissue activated and different regions of the brain was associated with the changes of these outcomes after surgery. Methods: Data from a long-term prospective cohort of 32 Parkinson's disease patients with subthalami

SUBMITTER: Cury RG 

PROVIDER: S-EPMC7028764 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature