Mechano-calcium and mechano-electric feedbacks in the human cardiomyocyte analyzed in a mathematical model.

ABSTRACT: Experiments on animal hearts (rat, rabbit, guinea pig, etc.) have demonstrated that mechano-calcium feedback (MCF) and mechano-electric feedback (MEF) are very important for myocardial self-regulation because they adjust the cardiomyocyte contractile function to various mechanical loads and to mechanical interactions between heterogeneous myocardial segments in the ventricle walls. In in vitro experiments on these animals, MCF and MEF manifested themselves in several basic classical phenomena (e.g., load dependence, length dependence of isometric twitches, etc.), and in the respective responses of calcium transients and action potentials. However, it is extremely difficult to study simultaneously the electrical, calcium, and mechanical activities of the human heart muscle in vitro. Mathema

SUBMITTER: Balakina-Vikulova NA 

PROVIDER: S-EPMC7028825 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature