CXCR4 or CXCR7 antagonists treat endometriosis by reducing bone marrow cell trafficking.

ABSTRACT: Adult stem cells have a major role in endometrial physiology, including remodelling and repair. However, they also have a critical role in the development and progression of endometriosis. Bone marrow-derived stem cells engraft eutopic endometrium and endometriotic lesions, differentiating to both stromal and epithelial cell fates. Using a mouse bone marrow transplantation model, we show that bone marrow-derived cells engrafting endometriosis express CXCR4 and CXCR7. Targeting either receptor by the administration of small molecule receptor antagonists AMD3100 or CCX771, respectively, reduced BM-derived stem cell recruitment into endometriosis implants. Endometriosis lesion size was decreased compared to vehicle controls after treatment with each antagonist in both an early growth and esta

SUBMITTER: Pluchino N 

PROVIDER: S-EPMC7028867 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature