Nongenic cancer-risk SNPs affect oncogenes, tumour-suppressor genes, and immune function.

ABSTRACT:

Background

Genome-wide association studies (GWASes) have identified many noncoding germline single-nucleotide polymorphisms (SNPs) that are associated with an increased risk of developing cancer. However, how these SNPs affect cancer risk is still largely unknown.

Methods

We used a systems biology approach to analyse the regulatory role of cancer-risk SNPs in thirteen tissues. By using data from the Genotype-Tissue Expression (GTEx) project, we performed an expression quantitative trait locus (eQTL) analysis. We represented both significant cis- and trans-eQTLs as edges in tissue-specific eQTL bipartite networks.

Results

Each tissue-specific eQTL network is organised into communities that group sets of SNPs and functionally related genes. When mapping cancer-risk SNPs

SUBMITTER: Fagny M 

PROVIDER: S-EPMC7028992 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature