Unique metabolite preferences of the drug transporters OAT1 and OAT3 analyzed by machine learning.

ABSTRACT: The multispecific organic anion transporters, OAT1 (SLC22A6) and OAT3 (SLC22A8), the main kidney elimination pathways for many common drugs, are often considered to have largely-redundant roles. However, whereas examination of metabolomics data from Oat-knockout mice (Oat1 and Oat3KO) revealed considerable overlap, over a hundred metabolites were increased in the plasma of one or the other of these knockout mice. Many of these relatively unique metabolites are components of distinct biochemical and signaling pathways, including those involving amino acids, lipids, bile acids, and uremic toxins. Cheminformatics, together with a "logical" statistical and machine learning-based approach, identified a number of molecular features distinguishing these unique endogenous subs

SUBMITTER: Nigam AK 

PROVIDER: S-EPMC7029110 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature