The human protein haptoglobin inhibits IsdH-mediated heme-sequestering by Staphylococcus aureus.

ABSTRACT: Iron is an essential nutrient for all living organisms. To acquire iron, many pathogens have developed elaborate systems to steal it from their hosts. The iron acquisition system in the opportunistic pathogen Staphylococcus aureus comprises nine proteins, called iron-regulated surface determinants (Isds). The Isd components enable S. aureus to extract heme from hemoglobin (Hb), transport it into the bacterial cytoplasm, and ultimately release iron from the porphyrin ring. IsdB and IsdH act as hemoglobin receptors and are known to actively extract heme from extracellular Hb. To limit microbial pathogenicity during infection, host organisms attempt to restrict the availability of nutrient metals at the host-pathogen interface. The human acute phase protein haptoglobin (Hp) prot

SUBMITTER: Mikkelsen JH 

PROVIDER: S-EPMC7029131 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature