Staphylococcus epidermidis MSCRAMM SesJ Is Encoded in Composite Islands.

ABSTRACT: Staphylococcus epidermidis is a leading cause of nosocomial infections in patients with a compromised immune system and/or an implanted medical device. Seventy to 90% of S. epidermidis clinical isolates are methicillin resistant and carry the mecA gene, present in a mobile genetic element (MGE) called the staphylococcal cassette chromosome mec (SCCmec) element. Along with the presence of antibiotic and heavy metal resistance genes, MGEs can also contain genes encoding secreted or cell wall-anchored virulence factors. In our earlier studies of S. epidermidis clinical isolates, we discovered S. epidermidis surface protein J (SesJ), a prototype of a recently discovered subfamily of the microbial surface component recognizing adhesive matrix mol

SUBMITTER: Arora S 

PROVIDER: S-EPMC7029136 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature