Respiratory Viral Infection Alters the Gut Microbiota by Inducing Inappetence.

ABSTRACT: Respiratory viral infections are extremely common, but their impacts on the composition and function of the gut microbiota are poorly understood. We previously observed a significant change in the gut microbiota after viral lung infection. Here, we show that weight loss during respiratory syncytial virus (RSV) or influenza virus infection was due to decreased food consumption, and that the fasting of mice altered gut microbiota composition independently of infection. While the acute phase tumor necrosis factor alpha (TNF-α) response drove early weight loss and inappetence during RSV infection, this was not sufficient to induce changes in the gut microbiota. However, the depletion of CD8⁺ cells increased food intake and prevented weight loss, resulting in a reversal of the gut mi

SUBMITTER: Groves HT 

PROVIDER: S-EPMC7029140 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature