Comparative effects of 18 antipsychotics on metabolic function in patients with schizophrenia, predictors of metabolic dysregulation, and association with psychopathology: a systematic review and network meta-analysis.

ABSTRACT:

Background

Antipsychotic treatment is associated with metabolic disturbance. However, the degree to which metabolic alterations occur in treatment with different antipsychotics is unclear. Predictors of metabolic dysregulation are poorly understood and the association between metabolic change and change in psychopathology is uncertain. We aimed to compare and rank antipsychotics on the basis of their metabolic side-effects, identify physiological and demographic predictors of antipsychotic-induced metabolic dysregulation, and investigate the relationship between change in psychotic symptoms and change in metabolic parameters with antipsychotic treatment.

Methods

We searched MEDLINE, EMBASE, and PsycINFO from inception until June 30, 2019. We included blinded, randomised cont

SUBMITTER: Pillinger T 

PROVIDER: S-EPMC7029416 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature