Hyaluronan Degradation by Cemip Regulates Host Defense against Staphylococcus aureus Skin Infection.

ABSTRACT: Staphylococcus aureus is a major human bacterial pathogen responsible for deep tissue skin infections. Recent observations have suggested that rapid, localized digestion of hyaluronic acid in the extracellular matrix (ECM) of the dermis may influence bacterial invasion and tissue inflammation. In this study we find that cell migration-inducing protein (Cemip) is the major inducible gene responsible for hyaluronan catabolism in mice. Cemip^-/- mice failed to digest hyaluronan and had significantly less evidence of infection after intradermal bacterial challenge by S. aureus. Stabilization of large-molecular-weight hyaluronan enabled increased expression of cathelicidin antimicrobial peptide (Camp) that was due in part to enhanced differentiation of preadipocytes to adipocytes, as

SUBMITTER: Dokoshi T 

PROVIDER: S-EPMC7029423 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature