Physico-chemical properties and gestational diabetes predict transplacental transfer and partitioning of perfluoroalkyl substances.

ABSTRACT:

Background

Per- and polyfluoroalkyl substances (PFASs) are a growing public health concern. Some longer chain PFASs bioaccumulate and many compounds persist in the environment for long time periods. Recent studies have established their ability to pass through placenta, yet data on the transplacental transfer efficiency and partitioning of short and long chain PFASs in blood matrices are limited.

Objectives

To assess predictors of the partitioning of 17 PFAS compounds detected in the maternal serum, umbilical cord serum and whole cord blood samples from matched mother-newborn pairs from two Faroe Islands cohorts.

Methods

We examined 151 mother-newborn pairs from two successive Faroese birth cohorts. Cord:maternal serum (transplacental transfer) and serum:whole cord bl

SUBMITTER: Eryasa B 

PROVIDER: S-EPMC7029428 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature